Happy to give some suggestions for your Italian holiday!
The way from Florence to Rome and back is protagonist of one of my blog posts 🙂
There are really many enchanting sights you could visit on the journey, especially the Val d’Orcia, the Trasimeno Lake, Orvieto, Civita di Bagnoregio and the Bolsena Lake.
As you don’t need to drive via Rome to Amalfi, you might consider passing through the beautiful Umbria region to visit Assisi, Perugia, and Todi, in addition to the mentioned Orvieto.
On your way south to Amalfi I highly recommend a visit to Cassino and the wonderful Abbey of Montecassino, and the stunning Reggia di Caserta.
Feel free to contact me again,
have a nice weekend,